Publications
Huang H, Shi CH, Yang W, Piña-Crespo JC, Bhatnagar J, Curatolo J, Murad R, Shah P, Campos A, Houser A, Porritt RA, Van Vo G, Xiao Q, Zhang T, Feng S, Yip KY, Huang TY. SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain. Science Advances. 2026. 12(29):eaed6825. DOI: 10.1126/sciadv.aed6825
2026
Guo Y, Li T, Tuomivaara ST, Teo CF, Feng S, Chalkley RJ, Zhu R, Cheng T, Li KH, Chen W, Simon A, Jin P, Younger S, Yong AJH, Li K, Li K, Burlingame AL, Jan LY, Jan YN. Identification of the peptide Vulnusin, a wound signal that mediates mechanical-injury-induced nociception in Drosophila. Neuron. 2025. 113(20):3352–3362. DOI: 10.1016/j.neuron.2025.09.007
2025
Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY. Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase. Nature Communications. 2023. 14:4874. DOI: 10.1038/s41467-023-40410-x
2023
Cheng Y, Feng S, Puchades C, Ko J, Figueroa E, Chen Y, Wu H, Gu S, Han T, Li J, Ho B, Shoichet B, Jan YN, Jan L. Identification of a conserved drug binding pocket in TMEM16 proteins. Research Square. 2022. rs.3:rs-1296933. DOI: 10.21203/rs.3.rs-1296933/v1
2022
Wang TA, Chen C, Huang F, Feng S, Tien J, Braz JM, Basbaum AI, Jan YN, Jan LY. TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures. Proceedings of the National Academy of Sciences. 2021. 118(20):e2023342118. DOI: 10.1073/pnas.2023342118
2021
Wang F, Liu Y, Yu Z, Li S, Feng S, Cheng Y, Agard DA. General and robust covalently linked graphene oxide affinity grids for high-resolution cryo-EM. Proceedings of the National Academy of Sciences. 2020. 117(39):24269–24273. DOI: 10.1073/pnas.2009707117
2020
Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y. Cryo-EM studies of TMEM16F calcium-activated ion channel suggest features important for lipid scrambling. Cell Reports. 2019. 28(2):567–579.e4. DOI: 10.1016/j.celrep.2019.06.023
2019
Dang S, Feng S, Tien J, Jan YN, Jan LY, Cheng Y. Investigation of TMEM16 family proteins using single particle cryo-EM. 第六届全国冷冻电子显微学与结构生物学专题研讨会论文集. 2019.
Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Jan YN, Minor DL Jr, Cheng Y, Jan LY. Cryo-EM structures of the TMEM16A calcium-activated chloride channel. Nature. 2017. 552(7685):426–429. DOI: 10.1038/nature25024
2017
Feng S. TRPC channel structure and properties. In: Transient Receptor Potential Canonical Channels and Brain Diseases. 2017. 9–23. DOI: 10.1007/978-94-024-1088-4_2
Su Y, Yuan Y, Feng S, Ma S, Wang Y. High frequency stimulation induces sonic hedgehog release from hippocampal neurons. Scientific Reports. 2017. 7:43865. DOI: 10.1038/srep43865
Feng S, Ma S, Jia C, Su Y, Yang S, Zhou K, Liu Y, Cheng J, Lu D, Fan L, Wang Y. Sonic hedgehog is a regulator of extracellular glutamate levels and epilepsy. EMBO Reports. 2016. 17(5):682–694. DOI: 10.15252/embr.201541569
2016
Feng S, He Z, Li H, Wang Y. Ca²⁺ signaling initiated by canonical transient receptor potential channels in dendritic development. Neuroscience Bulletin. 2015. 31(3):351–356. DOI: 10.1007/s12264-014-1511-7
2015
Feng S, Li H, Tai Y, Huang J, Su Y, Abramowitz J, Zhu MX, Birnbaumer L, Wang Y. Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake. Proceedings of the National Academy of Sciences. 2013. 110(27):11011–11016. DOI: 10.1073/pnas.1309531110
2013
He Z, Jia C, Feng S, Zhou K, Tai Y, Bai X, Wang Y. TRPC5 channel is the mediator of neurotrophin-3 in regulating dendritic growth via CaMKIIα in rat hippocampal neurons. The Journal of Neuroscience. 2012. 32(27):9383–9395. DOI: 10.1523/JNEUROSCI.6363-11.2012
2012
Tai Y, Feng S, Du W, Wang Y. Functional roles of TRPC channels in the developing brain. Pflügers Archiv – European Journal of Physiology. 2009. 458(2):283–289. DOI: 10.1007/s00424-008-0618-y
2009
Tai Y, Feng S, Ge R, Du W, Zhang X, He Z, Wang Y. TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway. Journal of Cell Science. 2008. 121(14):2301–2307. DOI: 10.1242/jcs.026906